The former catcher, who spent 13 of his 14 Major League seasons in Philadelphia and holds the franchise record for games caught, before playing his final season in 2007 with his hometown Los Angeles Dodgers, will officially retire as a Phillie on June 1.
The last player to end his career in this manner was Doug Glanville in 2005.
"Philadelphia has always been a second home to me, so I'm really looking forward to this," said Lieberthal in a statement. "I spent half my life there and still follow the team closely on television."